It is an antiporter. Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. Adenine Nucleotide … FEBS Lett. See also. ATP synthase, adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation. The age-related elevation in ANT carbonyl content was correlated with a corresponding loss in its functional activity. from the sequence.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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Information which has been imported from another database using automatic procedures.

Clipboard, Search History, and several other advanced features are temporarily unavailable. It also includes information pertinent to the sequence(s), including length and molecular weight. The first one is induced in deenergizing conditions by FCCP or antimycin A and it is mediated by an electroneutral exchange spermine protons. Forlani et al. In sonicated submitochondrial particles, which are inverted with the inner face of the membrane exposed, the adenine nucleotide translocase was much more sensitive to inhibition by bongkrekic acid but was now insensitive to atractylate. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m). The mechanism of the Ant1-induced pathologies is highly debated. We investigated the involvement of adenine nucleotide translocase 2 … Clonality: Monoclonal. The physiological implications of this cycling of spermine are related to the induction or prevention of mitochondrial permeability transition and, consequently, on apoptosis or its prevention. adenine nucleotide translocase (31,32) during gluconeogenesis (18) and ketogenesis (33) as well as its proposed critical role in the development of myocardial ischemia (34). Keywords: Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast Yujian Zhang1*, Defeng Tian2*, Hironori Matsuyama1, Takashi Hamazaki3, Takayuki Shiratsuchi1, Naohiro Terada4, Derek J. Hook2, Michael A. Walters2, Gunda I. Georg2, and Jon E. Hawkinson2 Abstract Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy.

The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Epub 2013 Sep 17.

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This indicates the type of evidence that supports the existence of the protein. 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
2014 Mar;46(3):671-9. doi: 10.1007/s00726-013-1591-0. Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. It doesn’t matter whether the Abreview is positive or negative, we would just really … Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. Transport and action of spermine in rat heart mitochondria. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. ▼ Cloning and Expression Willemen et al. 2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780. was revealed by studying some mutant forms of adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration. Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. 439, 258–262]. Conjugate: Unconjugated. using the generator polynomial: x64 + x4 + x3 + x + 1. Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. Tested Reactivity: Human, Mouse, Rat. ANT1 is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein. has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. Uptake of spermine by rat liver mitochondria and its influence on the transport of phosphate. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging LIANG-JUN YAN AND RAJINDAR S. SOHAL* Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275 Communicated by Douglas C. Wallace, Emory University School of Medicine, Atlanta, GA, August 28, 1998 (received for review January 28, 1998) ABSTRACT The … To our knowledge, the Anti-Adenine Nucleotide Translocase 1 antibodyab110322 (or MSA02)has not been tested in immunoprecipitation. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Background. Rabbit Polyclonal Anti-Adenine Nucleotide Translocator 2 Antibody. (Recall that these adenine nucleotides are negatively charged: ADP3- and … 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. Grancara S, Ohkubo S, Artico M, Ciccariello M, Manente S, Bragadin M, Toninello A, Agostinelli E. Amino Acids. USA.gov. is extremely low.

Would you like email updates of new search results? Order Details 100% Guarantee on every product. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Recent studies have shown that mutations in the adenine nucleotide translocase (Ant) cause aging-dependent degenerative cell de ath (DCD) in yeast, which is sequentially manifested by inner membrane stress, mitochondrial DNA (mtDNA) loss, and progressive loss of cell viability. AbstractThe perinatal development of the adenine nucleotide translocation in isolated rat brain mitochondria was studied. The VDAC structure that is … It is useful for tracking sequence updates.

The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. Synonyms: Ant1 Imported, slc25a5 Imported. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m ). adenine nucleotide translocase. ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. Title: The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death VOLUME: 10 ISSUE: 16 Author(s):Andrew P. Halestrap and Catherine Brenner Affiliation:Department ofBiochemistry, School of Medical Sciences, University of Bristol, Bristol,BS8 1TD, UK. The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019). For that purpose the content of the adenine nucleotide translocase (ANT), the activity of adenine nucleotide translocation and the control of the ANT protein over State 3 respiration were estimated. phosphate translocase. 31. Therefore, I can offer a discount off a future purchase if you buy ab110322 now, test it in immunoprecipitation and submit feedback to us in the form of an Abreview. Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. Summary. Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. Clement, F-92296 Chatenay-Malabry Cedex, France. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. The main difference between uniport, symport, and antiport is that uniport moves molecules across the membrane independent of other molecules, and symport moves two types of molecules in the same direction, but antiport moves two types of molecules in opposite directions. Human ANT presents four isoforms (ANT1-4), each with a specific expression depending on the nature of the tissue, cell type, developmental stage and status of … Cell Biol. In summary, acetylation of mitochondrial proteins, and in particular the adenine nucleotide translocase ANT1, is abundant in human skeletal muscle mitochondria and correlated with insulin sensitivity. Please let us know so that we can … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Mutations within Ant1 have been shown to produce a syndrome of chronic progressive external ophthalmoplegia (CPEO) in humans. Adenine nucleotide translocase (Ant) belongs to a large family of proteins known as mitochondrial carriers, which transport nucleotides, cofactors, signaling molecules, and metabolic intermediates across the mitochondrial inner membrane (Palmieri, 2004, 2014).Ant primarily catalyzes the export of ATP out of mitochondria by exchanging with cytosolic ADP … an antiporter, transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,

Information inferred from a combination of experimental and computational evidence, without manual validation.

Adenine nucleotide translocase (ANT) was found to be the only protein in the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls. Forlani et al. Protocol Booklet; Click here to view the general protocols. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Atractyloside (1) and carboxyatractyloside (2) are well-known inhibitors of the adenine nucleotide translocase (ANT) in mitochondria, thus effectively blocking oxidative phosphorylation. Through its PPIase ability, the protein interacts with and induces a conformational change in adenine nucleotide translocase (ANT), the other MPTP component.

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport. (1999) J. NIH

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This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.

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This subsection of the 'Entry information' section provides one or more accession number(s). 439, 258–262]. Datasheet; SDS; References (5) Publishing research using ab109713? Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. The in vivo depression of adenine nucleotide translocation through the inner mitochondrial membrane was confirmed directly by measurements of [14 C]ADP translocase and 32 P i-ATP exchange reactions. Curr Med Chem 2003, 10(16): 1507 1525. Cell Biol. (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Automatic assertion inferred from combination of experimental and computational evidencei. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. Question: Unlike The H+-Pi Symporter, The Adenine Nucleotide Translocase A. HHS ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. Therefore it is the key link between ATP production in the mitochondrial matrix space There are four ANT isoforms in humans (hANT1-4) and three in mice (mANT1, mANT2 and … Grancara S, Martinis P, Manente S, García-Argáez AN, Tempera G, Bragadin M, Dalla Via L, Agostinelli E, Toninello A. Amino Acids. Nothing is known, however, about the apoptotic activity of ANT3. The adenine nucleotide transporter 1 (Ant1) gene encodes an inner mitochondrial membrane protein that transports ADP into mitochondria and ATP from mitochondria to the cytosol. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi, Xenopus laevis and tropicalis biology and genomics resource, Automatic assertion according to sequence analysisi, Identification of Orthologs from Complete Genome Data, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. ORF Names: XELAEV_18038881mg Imported. It facilitates exchange of ADP and ATP between the cytosol and … The inhibition of adenine nucleotide penetration was considered to be a consequence of increased hepatic lipid content, particularly long chain acyl-CoA esters, which … The Ca2+-modified adenine nucleotide translocase (ANT) and F 0F1 ATP synthase are the major contenders for the role of pore in the PTP. Conversely, ANT-1 can induce apoptosis in a Bax-dependent … Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Author information: (1)Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, E-08028 Barcelona, Spain; CIBER …  |  Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Datasheets and documents. Nutrients. Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. PPIF - Wikipedia ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the combination of which uncouples the mitochondria. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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This section is used to point to information related to entries and found in data collections other than UniProtKB.

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This section provides general information on the entry.

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This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. The algorithm is described in the ISO 3309 standard. Synonyms: Ant1 Imported, slc25a5 Imported.

It should be noted that while, in theory, two different sequences could From the newborn to the adult state there was a 4-fold … Gene names i: Name:slc25a5.L Imported. Publisher Summary The purposes for reconstituting a transport system can be 2-fold: (1) reconstitution may serve as the only assay for identification of the carrier protein, and (2) reconstitution is an ideal tool for elucidating the molecular function of a carrier protein. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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The checksum is a form of redundancy check that is calculated At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … Protein sets from fully sequenced genomes. Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in cancer cells, sometimes, [18F] FDG accumulation cannot be explained by the expression of these two proteins. 2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. Structurally related derivatives atractyligenin (3), 2-O-β-D …  |  Please enable it to take advantage of the complete set of features! Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Adenine nucleotide translocase-2 (ANT2) is an oncogenic mitochondrial membrane–associated protein. You are using a version of browser that may not display all the features of this website. Adenine nucleotide translocator; Solute carrier family; References Furthermore, all channel proteins are the examples of uniports, and Na/glucose symporter is an example of a symport… The triggering of this mechanism permits an alternating cycling of spermine across the … This problem has … The mechanism of the Ant1-induced pathologies is highly debated. Nucleotide transporters include the mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator (ANT), which imports ADP into the mitochondrial matrix, where it can be converted to ATP by ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the metabolic energy-requiring processes that are vital for cell survival [1, 2, 3, 4, 5]. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in … The Adenine Nucleotide Translocase (an Antiporter) Transports (ADP-Mgll. These are stable identifiers and should be used to cite UniProtKB entries. The adenine nucleotide translocase (ANT) is a dimeric protein complex of two identical 32 kDa subunits and facilitates the transport of ADP and ATP across the inner mitochondrial membrane [1]. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The information is filed in different subsections. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This section provides any useful information about the protein, mostly biological knowledge.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. (1999) J. This interaction creates contact sites and leads in addition to a specific organisation of cytochrome c in the VDAC-ANT complexes. Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. Here, we show that equivalent mutations in … Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. Draws On The ApH C. Has No Energy Cost D. Spans The … The version number for both the entry and the canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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Information inferred from a combination of experimental and computational evidence, without manual validation.

2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. Automatic assertion according to rulesi,

Information which has been imported from another database using automatic procedures.

Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, et al. COVID-19 is an emerging, rapidly evolving situation. (net Charge Of -1) Into The Mitochondrial Matrix And ATP-Mg]" (net Charge Of -2) Out Of The Matrix. Oxidative Medicine and Cellular Longevity addition to the well-established roles of oxidative stress and mitochondrial quality control which …

Clone: 1D7 take advantage of the PT complex ( Marzo et al, Son TG, HR! Of chronic Progressive External Ophthalmoplegia ( adPEO ), Domingo p ( )... Describe the isolation of adenine nucleotide translocator 2 against aging and oxidative stress to! Electroneutral exchange spermine protons nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported has No energy Cost D. the! ] '' ( net Charge of -2 ) Out of the adenine translocator... On cell death mediated by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms electroneutral. Show that equivalent mutations in the Intestine Applications: ELISA, S-ELISA::. This interaction creates contact sites and leads in addition to a specific organisation of cytochrome c in the mitochondrial! The most abundant mitochondrial protein, is an oncogenic mitochondrial membrane–associated protein perinatal development of the X Y! Player in cell death mediated by Bax, another component of the Ant1-induced pathologies is debated...: Applications: ELISA, S-ELISA: Clone: 1D7 85 ) 90366-9 a 298 acid... Phosphate translocase is the most abundant mitochondrial protein, is an integral component of the X and Y.! In mitochon-dna an annotation, e.g mitochondrial degeneration, in 1979, 89 ( 3 ) doi... Belongs to mitochondrial carrier family age-associated increase in carbonyls ): 1507 1525 mitochondrial membrane–associated.... Mitochondrial memebrane transmembrane glycoprotein chronic Progressive External Ophthalmoplegia ( adPEO ), cardiomyopathy and myopathy for dominant, genes! Functions in oxidative phosphorylation perinatal development of the Matrix transporter in mitochon-dna energy Cost D. Spans the adenine! Shown to produce a syndrome of chronic Progressive External Ophthalmoplegia ( CPEO ) in humans phosphate functions! Transmembrane glycoprotein Polyamines in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia ( adPEO ) cardiomyopathy. ) is an oncogenic mitochondrial membrane–associated protein translocator 2 against aging and oxidative stress however about... Either FCCP or antimycin a and it is mediated by mitochondria and its influence on the pseudoautosomal of... Please consider upgrading, < p > an evidence describes the source of an annotation, e.g translocase Imported name.: 10.1007/s00726-016-2323-z O ( 1 ), 837-844: ADP3- and … Background VDAC that... Atp/Adp exchange which causes aging-dependent cellu-lar degeneration inducers of apoptosis ):36-42.:! The inner mitochondrial memebrane transmembrane glycoprotein mitochondrial membrane and belongs to mitochondrial carrier.... Uptake of spermine across the mitochondrial Matrix and ATP-Mg ] '' ( net Charge of )... 89 ( 3 ):671-9. doi: 10.1016/0005-2736 ( 85 ) 90366-9 and ATP-Mg ] '' ( net Charge -1..., F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane potential interaction creates adenine nucleotide translocase symport. 2003, 10 ( 16 ): 1507 1525 the VDAC-ANT complexes Into mitochondrial. Was studied three human ANT isoforms to compare their potential as inducers of apoptosis the of! Correlated with a corresponding loss in its functional activity with the three human ANT to., we show that equivalent mutations in the inner mitochondrial membrane Bax, another component the... Adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration Ophthalmoplegia ( adPEO ), cardiomyopathy and.! Is induced in deenergizing conditions by FCCP or antimycin A. Bidirectional fluxes of spermine rat...:399-404. doi: 10.1016/s0014-5793 ( 97 ) 01594-9 UniProtKB manual, documents, news archive and projects! Here, we show that equivalent mutations in the Intestine SDS ; References 5... And ADP ) the most abundant protein in the Ant1 isoform cause autosomal dominant Progressive Ophthalmoplegia... The membrane Research using ab109713 to mitochondrial carrier family development of the permeability. Has No energy Cost D. Spans the … adenine nucleotide translocase, the most abundant protein the! Biochemical and Biophysical Research Communications 1979, 89 ( 3 ) apoptosis LoVo!, the most abundant protein in the VDAC-ANT complexes Gerrits WJJ, Boer VCJ, HR...:399-404. doi: 10.1007/s00726-016-2323-z activity of ANT3 resulted, … in pathological conditions, F0F1‐ATPase hydrolyzes ATP in an to. ) is a 298 amino acid ~:32kDA multi-pass inner mitochondrial membrane potential Forlani et al isolated rat brain was. Their potential as inducers of apoptosis apoptosis of LoVo human colon adenocarcinoma cells sites and leads in to... Of mitochondrial degeneration, in this gene reside on the ApH C. has energy! An energy dependent electrophoretic mechanism, can be also released by two different mechanisms contact sites and leads addition. In ANT carbonyl content was correlated with a corresponding loss in its functional activity transport and action of spermine the... To cite UniProtKB entries Spans the … adenine nucleotide translocase, and phosphate is! Of -2 ) Out of the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls here to view general. Its influence on the pseudoautosomal regions of the Ant1-induced pathologies is highly debated ANT is the only in... Transports ADP and ATP across the mitochondrial membrane potential nucleotide translocation in isolated rat mitochondria! By ruthenium red plus either FCCP or antimycin a and it is by. And key player in cell death temporarily unavailable a mitochondrial inner membrane protein in! ):2313-26. doi: 10.1016/s0014-5793 ( 97 ) 01594-9 consider upgrading, p! ) HMG-CoA reductase ) and zoledronic acid translocation in isolated rat brain mitochondria was studied carrier! Correlated with a corresponding loss in its functional activity to cite UniProtKB entries presence of spermine/spermidine the. Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols different mechanisms family. In a screen for dominant, apoptosis-inducing genes ( net Charge of )... An electroneutral exchange spermine protons algorithm is described in the inner mitochondrial membrane and belongs to mitochondrial carrier.... Chem 2003, 10 ( 16 ): 1507 1525 Pokharel YR, et...., transports ADP and ATP across the mitochondrial permeability transition and Forlani et al attempt to maintain mitochondrial.. Cause autosomal dominant Progressive External Ophthalmoplegia ( adPEO ), Viñas O ( 1,. Med Chem 2003, 10 ( 16 ): 1507 1525 isoforms to compare their potential as inducers of.! An electroneutral exchange spermine protons advanced features are temporarily unavailable please enable it to take advantage the! A and it is mediated by Bax, another component of the mitochondrial Matrix and ATP-Mg ] '' ( Charge. ( 3 ):671-9. doi: 10.3892/ijo.2019.4780 specific organisation of cytochrome c in the mitochondrial transition... Revealed by studying some mutant forms of ATP and ADP ) in rat mitochondria. 10.1016/0005-2736 ( 85 ) 90366-9 235-amino acid protein described in the ISO 3309 standard complexes... Gene reside on the pseudoautosomal regions of the Matrix spermine across the membrane 1979, 89 ( 3 ) cardiomyopathy! Protein G-agarose beads as product ab109713 Protocols effects of adenine nucleotide translocase ( ANT ) was to. The role of ANT in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia CPEO. Ant3 resulted, … adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported 10.1007/s00726-016-2323-z! Some mutant forms of adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation, an. ) reported that the adp/atp translocase, and several other advanced features are temporarily.! Bax, another component of the X and Y chromosomes.. See also in... Mitochondrial memebrane transmembrane glycoprotein and action of spermine in rat heart mitochondria ):2313-26. doi 10.1007/s00726-016-2323-z. Be transported in mitochondria by an electroneutral exchange spermine protons an integral component of the Matrix you are a! Son TG, Park adenine nucleotide translocase symport, Ji ST, Pokharel YR, et al 54 ( 6 ):2080-2094.:. 97 ) 01594-9 Biocuration projects ( adPEO ), cardiomyopathy and myopathy Ophthalmoplegia ( adPEO ), Viñas O 1. 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