Guide for the Care and Use of Laboratory Animals (1996 ed. 0000009117 00000 n 0000002890 00000 n laboratory animals 1. laboratory animals mehul ramanlal chorawala department of pharmacology k. b. institute of pharmaceutical education and research a constituent college of kadi sarva vishwavidyalaya gh-6, sector-23 gandhinagar-382023, gujarat 2. 0000007266 00000 n 0000001951 00000 n These drugs are specifically formulated and supplied with information on in-dications, dose, dose frequency, routes of administration, and safety. %PDF-1.4 Note: If the amount of blood volume removed is 7.5% of total blood volume, allow 1 week recovery; if amount removed is 10%, allow 2 weeks recovery; if amount removed is 15%, allow 4 weeks recovery. 4 0 obj Laboratory/Research Skills for Science Resume List of skills to assist with resumes, cover letters and interviews Animal Care Handle and restrain Weigh animals Breed various species Clean cages Administer injections Prepare special diets Anesthetize Maintain and evaluate animal records Prepare for sterile surgical procedures techniques into the field of laboratory animal anaesthesia. Monitoring 7. Best Practices 6. H�}T�r�0�{�����;�*���#M�qRצ]䱐A1j ��I�������������-����#JC�*US���~/��� ًC��rp� I���� �?�F�R֖���”C�j1�Q[{��RT�+a2�H8��r�}1$�N� F ���0y(�VSm�&1��5�����[� }����t�1 �r�@��ۆ��:��p3Ȭ8�(����jT=��?��#�C�5��z�ޙM����4���������@-. This handbook attempts to provide a basic guide to anaesthesia for research workers and animal technicians. �y�%�$^�M���A�B���]*�L�;G����v���)`�셗"��s��82��5�Y�XGVP�I?8��zZ�yY߻9n�e���71�7U;��W-�Cm�Fmʳvm��(�{0�Xi�� �;~]|>g�*>)���O�_�O��ԋDf�4PY 1ka��ڏ�{RXB�&�ta�-k�蓶�Cȹ �!l�n*΍��=U? Table of Contents 1. • Scientifically-valid research designed to reduce, refine or replace the need for laboratory animals is encouraged. Dogs and cats must be obtained from designated breeding establishments. The focus Laboratory Animals 1. The aim was to refine administration procedures and improve animal welfare and science. 0000006303 00000 n SOT Animals in Research Public Policy Statement 1999 Research involving laboratory animals is necessary to ensure and enhance human and animal health and Proper handling of laboratory animals goes a along way to ensure reproducible results are obtained. If you need to print pages from this book, we recommend downloading it as a PDF. The paper covered the most commonly used routes in common laboratory species. Blood sample collection in small laboratory animals, J Pharmacol Pharmacother, 2010 Jul-Dec; 1(2); 87-93. 0000005391 00000 n It is organized into five chapters that cover the subject areas of 1) key defining concepts, including applicability, a brief review of the ethical principles in the … 0000002783 00000 n 2 0 obj Introduction Laboratory animals are used for different studies It may include bioassay, preclinical studies etc. 35, 1-41. <> Blood may be collected from animals which are to survive the procedure or at sacrifice as a terminal event. 0000004490 00000 n Collection of blood from laboratory animals is frequently necessary for a variety of experimental uses including determination of pharmacokinetics, antibody production, clinical pathology evaluation, etc. Section 495 of … ,c���s��L�S]�=�� �Ib endstream endobj 87 0 obj 280 endobj 61 0 obj << /Type /Page /Parent 57 0 R /Resources 62 0 R /Contents [ 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 80 0 R 82 0 R 84 0 R ] /Thumb 36 0 R /MediaBox [ 0 0 598 846 ] /CropBox [ 0 0 598 846 ] /Rotate 0 >> endobj 62 0 obj << /ProcSet [ /PDF /Text ] /Font << /F2 77 0 R /F9 63 0 R /F10 64 0 R /F11 66 0 R >> /ExtGState << /GS1 85 0 R >> >> endobj 63 0 obj << /Type /Font /Subtype /Type1 /Name /F9 /Encoding 65 0 R /BaseFont /Times-Roman >> endobj 64 0 obj << /Type /Font /Subtype /Type1 /Name /F10 /Encoding 65 0 R /BaseFont /Times-Italic >> endobj 65 0 obj << /Type /Encoding /Differences [ 1 /Agrave /Egrave /Igrave /Ograve /Ugrave /agrave /egrave /igrave /ograve 11 /Aacute /Eacute /Iacute /Oacute /Uacute /Yacute /aacute /eacute /iacute /oacute /uacute /yacute /Acircumflex /Ecircumflex /Icircumflex 27 /Ucircumflex /acircumflex /ecircumflex /icircumflex /ocircumflex 128 /ucircumflex /Atilde /Ntilde /Otilde /atilde /ntilde /otilde /Adieresis /Edieresis /Idieresis /Odieresis /Udieresis /Ydieresis /adieresis /edieresis /idieresis /odieresis /udieresis /ydieresis /Aring /aring /Ccedilla /ccedilla /Scaron /Zcaron /scaron /zcaron /Eth /eth /Thorn /thorn /Ocircumflex /minus 209 /trademark /copyright /logicalnot /registered 214 /brokenbar /degree /plusminus /twosuperior /threesuperior /mu /onesuperior /onequarter /onehalf /threequarters /multiply ] >> endobj 66 0 obj << /Type /Font /Subtype /Type1 /Name /F11 /Encoding 65 0 R /BaseFont /Times-Bold >> endobj 67 0 obj 686 endobj 68 0 obj << /Filter /FlateDecode /Length 67 0 R >> stream Study in a typical gross anatomy laboratory is based primarily on dissection of animal cadav-ers. ILAR News 34(4):51-526. The Welfare of Laboratory Animals PDF.. 1992b. 0000009824 00000 n trailer << /Size 88 /Info 58 0 R /Root 60 0 R /Prev 78502 /ID[] >> startxref 0 %%EOF 60 0 obj << /Type /Catalog /Pages 57 0 R >> endobj 86 0 obj << /S 202 /T 290 /Filter /FlateDecode /Length 87 0 R >> stream the animal is anemic (below the normal PCV range for the species), or if the hemoglobin concentration is less than 10 g/dL, it is not safe to remove the volumes of blood listed above. Laboratory animals are animals used for research purposes for developing and testing medicines and vaccines for humans and other animals. 5 Last Revised December 20, 2016. Laboratory Animals: All Issues - Laboratory Animals. It is estimated that anywhere from 10% to 44% of animal care workers will develop allergic symptoms to the animals. Blood Collection Sites and Methods The following are frequently used sites for survival blood sampling from common laboratory animal species. • Guidelines on anesthesia and analgesia in laboratory animals, University of South Florida, 2009; 1-20. The prevention or minimization of animal pain, distress, or discomfort by the proper use of tranquilizers, anesthetics, and analgesics is scientifically and ethically essential to the humane care, use, and treatment of research animals. 2020 2020 Volume 54 Issue 6, Current Issue December 2020 , pp. 2000;29(5):32-37. List of Issues View. use in common laboratory species used in toxicity studies required by regulatory authorities; (ii) to provide consensus dosage levels for routine use that represent good practice in terms of ani-mal welfare and practicality; (iii) to produce a guide to dosage levels representing the upper limit of common practice, which leaves endobj Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. %���� Web: www.pcrm.org <> This report was drawn from the scientific community from industry, academia, and animal welfare organizations. Animal welfare is attracting increasing interest worldwide, but particularly from those in developed countries, who now have the knowledge and resources to be able to offer the best management systems for their farm animals, as well as potentially being able to offer plentiful resources for companion, zoo and laboratory animals. INTRODUCTION Selection of animal model Use of an animal phylogenetically closer to man Use of an animal in which the process under investigation is as close as possible 2. The international journal of laboratory animal science, technology, welfare and medicine, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the care and use of animals in biomedical research. 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Blood Sampling in Sheep ( pdf … 6 0 obj 0000000927 00000 n The domestic mouse, Mus musculus and related subspecies (see Mice and Rats as Laboratory Animals), is popular as a mammalian research model because of its small size, adaptability, docility, low husbandry costs, fecundity, well-defined health and genetic backgrounds, and relative ease of genetic manipulation.The development of genetic engineering techniques of inserting … *{~��ƅ �m��:?R��n��@��8�� >�����+l�����aq?�����}��?������+�D�W��W֙�'��^~�@�,|�b�X�,���\=h�������d�C��_{�b�4�S9����E���1�[�F���� Laboratory Animals. endobj Standardized nomenclature for transgenic animals. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses … 0000005412 00000 n Animal Care and Use Committee Page . Email: jbalcombe@pcrm.org. Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. {.s���|�������-2��LPȋ���͛�ο)� Wz�,�{a���"��M�ɿ���q}���b�͞ʬ.�l7�����&���)�!z�H�tWca���"�gQj�����7< endstream endobj 69 0 obj 716 endobj 70 0 obj << /Filter /FlateDecode /Length 69 0 R >> stream ;��GD��� ��]�P�;���/��ַ�J���)�Ojb2F�5�� 1¼��0���ap�n����Sp��F((��&���}�E�U�� ҸirW�ƣy6�b���,������-sgJg7o�����ge]. • Research animals must be used in a responsible manner. However, there is a growing body of literature on environmental-enrichment strategies for many of the common laboratory animal species, and the Guide (NRC 1996a) provides an impetus for institutions to evaluate and incorporate enrichment measures into their animal care and use program for all species where appropriate. 0000001842 00000 n 59 0 obj << /Linearized 1 /O 61 /H [ 982 393 ] /L 79810 /E 10068 /N 9 /T 78512 >> endobj xref 59 29 0000000016 00000 n Common Sites for Blood Collection: Laboratory Animals. Laboratory Animals (2006) 40 , 217 235 REVIEW ARTICLE Correspondence: J P Balcombe. 0000001597 00000 n Healthy and well being of lab. Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals 3rd Edition continues as the most comprehensive reference on in vivo animal studies. 0000009138 00000 n NRC (National Research Council). April 1967 - December 2020 Select an issue. 0000001375 00000 n 0000001354 00000 n 3 0 obj %PDF-1.2 %���� ), and the Animal Welfare Act (Public Law 89-544). Animals used for laboratory research or teaching purposes at the University of Montana (UM) include mice, rats, guinea pigs, rabbits, hamsters, and birds. Guide to anaesthesia for research purposes for developing and testing medicines and vaccines for humans other... Pdf … the clinical Chemistry of laboratory animals ( 1996 ed workers will eventually develop asthma! 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